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中药资源学教研室

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中药资源学教研室简介

中药资源学教研室目前有教师五名,均具有博士学位,其中高级职称2人,中级职称3人,一人为60后,其余四人均为80后,梯队合理,队伍年轻有朝气。学缘背景包括:药学、中药学、植物生物技术学、昆虫学、微生物学等方面,具有较强的学科交叉属性和鲜明的研究特色。

教学工作方面

讲授《中药资源科学考察概论》、《中药生物技术》、《药用动物学》、《菌物资源学》、《中药资源生态学》及实习、实验等共计11门课程,协助完成《药用植物学野外采集》教学任务。我室贾景明教授主导的沈阳药科大学中药资源科学考察活动荣获“2018年辽宁省本科高校教学成果一等奖”,主编“十三五”规划教材《中药生物技术》一部;研究生教材《分子生药学专论》一部,2020年被评为辽宁省优秀研究生教材,参编“十三五”规划本科教材3部:《中药生物技术》、《药用动物学》、分子生药学

科研平台情况

2010年主导建立“沈阳药科大学-韩国东亚大学分子生药学共建实验室”,

2019年获批“辽宁省濒危珍稀药材资源开发与应用专业技术创新中心”。

科研工作方面

(一)科研工作概

教研室拥有辽宁省科技创新领军人才一人,沈阳市领军人才一人;教研室成员承担“十一五”重大新药创制子课题一项,“十二五”国家科技支撑计划一项,“十三五”中医药重大专项一项,国家自然科学基金项目两项,省教育厅、科技厅课题十余项,校级人才项目2项,指导校内各级大学生创新训练项目十余项,承担研究经费总额1千余万元,迄今发表SCI期刊40余篇,获批中国发明专利授权10项。

(二)近年来教研室成员主持国家级科研项目

1.国自然青年基金:基于抑制血管新生的中药豨莶草抗类风湿关节炎药效物质基础和作用机制研究;

2.“十三五”国家重点研发计划:辽宁高品质道地中药材五味子、石柱参和苦参规模化种植及精准扶贫示范研究;

3.“十二五”国家科技支撑计划:五味子产业关键技术、综合开发利用研究;

4.国自然面上项目,筒鞘蛇菰、延龄草和神农香菊等3种土家族特色药材中抗炎药效物质基础的快速发现及作用机制研究;

5.“十一五”重大新药创制平台子课题:濒危珍稀和道地药材培育与质量控制子平台;

6. 五味子良种繁育、有效部位制备及新药开发,辽宁省创新药物孵化平台建设项目;

7.濒危珍稀和道地药材研究创新团队建设,中央财政支持地方高校发展专项资金-人才培养和创新团队建设项目。

(三)近年来教研室成员发表代表性科研论文:

A novel alkaloid from the seeds of Sophora alopecuroides L. Nat Prod Res., (2020)

ent-Pimarane diterpenoids from Siegesbeckia glabrescens with anti-inflammatory activity. Bioorganic Chemistry, (2020)

Six novel lignanoids with complex structures from Sigesbeckia glabrescens Makino with their cytotoxic activities. Fitoterapia. (2020)

Chemical constituents of Sophora flavescens Ait. and cytotoxic activities of two new compounds. Natural Product Research. (2020)

Constituents from the Seeds of Sophora Alopecuroides L. Molecules, 25, 411; (2020)

Comparative Studies on Polysaccharides, Triterpenoids, and Essential Oil from Fermented Mycelia and Cultivated Sclerotium of a Medicinal and Edible Mushroom, Poria Cocos. Molecules, 25, 1269; (2020)

Two new alcohol glycosides from the roots of Paeonia intermedia C. A. Meyer. J Asian Nat Prod Res. (2019)

Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer. Nat Prod Res. (2019)

A sensitive UPLC-MS/MS method for simultaneous determination of polyphenols and theaflavins in rat plasma: application to a pharmacokinetic study of Da Hong Pao tea. Biomed Chromatogr. (2019)

Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom. Nat Prod Res. (2019)

Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer. Nat Prod Res. (2019)

Optimization of Culture Condition for Ganoderic Acid Production in Ganoderma lucidum Liquid Static Culture and Design of a Suitable Bioreactor. Molecules. (2018)

Comparative Analysis of Chemical Composition, Anti-Inflammatory Activity and Antitumor Activity in Essential Oils from Siegesbeckia orientalis, S. glabrescens and S. Pubescens with an ITS Sequence Analysis. Molecules, (2018)

Wound Stress, an Unheeded Factor for Echinacoside Accumulation in Cistanche deserticol a Y. C. Ma. Molecules. (2018)

GC-MS Analysis of the Composition of the Essential Oil fromDendranthema indicumVar.AromaticumUsing Three Extraction Methods and Two Columns. Molecules. (2018)

Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. (2018)

Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase. J Asian Nat Prod Res. (2018)

Phenolic glycosidesand monoterpenoids from the roots of Euphorbiaebracteolata and their bioactivities, Fitoterapia, (2017)

Antioxidant  acetophenone glycosides from the roots of Euphorbia ebracteolata Hayata, Nat Prod Res, (2017)

Phenolic acids from Balanophora involucrata and theirbioactivities, Fitoterapia, (2017)

Monitoring the Consistency Quality and Antioxidant Activity of DHP Teas by HPLC Fingerprinting. J Chromatogr Sci. (2017)

(四)主要科研方向:

中药生物技术、中药有效成分的生物合成途径与代谢调控研究、天然产物研究、中药资源学、药用动物学、内生菌的分离与活性成分筛选、中药的分子鉴定技术、中药活性成分研究、中药道地性形成机制研究等。