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天然药物化学教研室

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张雪 教师的资料

张雪

姓名: 张雪

性别: 女

籍贯:沈阳市

联系电话: 024-23993994

E-Mail syzxalice@163.com

个人主页:

职称/职务: 副教授

通讯地址: 沈阳市沈河区文化路103号,沈阳药科大学81号信箱

邮政编码:110016

学习/工作经历:

1997——2001年沈阳药科大学药学专业(理科基地班)本科阶段学习

2001——2005年沈阳药科大学天然药物化学专业研究生阶段学习

2006——2008年清华大学生物学博士后流动站/深圳清华大学研究院博士后科研工作站进行博士后科研工作

2008年至今沈阳药科大学中药学院教师

兼职情况:

科研/获奖情况:

2007年国家自然科学基金《采用视黄醇受体活性筛选体系从中药和天然药物中寻找抗癌活性物质

2007中国博士后科学基金采用视黄醇受体活性筛选体系从中药和天然药物中寻找抗癌活性物质

2010辽宁省教育厅科学技术研究项目《金银花防治心血管疾病活性成分及活性部位指纹图谱研究》

2013辽宁省教育厅科学技术研究项目《薄叶胡桐作用于视黄醇X受体的抗癌活性成分研究

2013天然药物活性物质与功能国家重点实验室开放课题荚果蕨中抗流感病毒活性先导化合物的发现和构效关系研究

2006年中国药学会学术年会优秀论文二等奖《金钗石斛中联苄类和酚酸类成分的抗氧化活性研究

2012辽宁省自然科学学术成果奖学术论文类三等奖《New Isocourmarin and Phthalide Derivatives from the Rhizomes of Matteuccia orientalis

教学/指导研究生情况:

承担本科《天然药物化学》、《有机化合物波谱解析》、《国外植物药研究与开发》的理论课教学工作,以及本科《天然药物化学实验》、研究生《植化方法学实验》的教学工作,获2014年校青年教学标兵。

指导已毕业硕士研究生9名,在读硕士研究生9名。

发表论文/出版著作:

1. Guan Wang, Ling-Juan Zhu, Yu-Qian Zhao, Su-Yu Gao, De-Juan Sun, Jing-Quan Yuan, Yu-Xin Huang, Xue Zhang*, Xin-Sheng Yao*. A natural product from Cannabis sativa subsp. sativa inhibits homeodomain-interating protein kinase 2 (HIPK2), attenuating MPP+-induced apoptosis in human neuroblastoma SH-SY5Y cells. Bioorganic chemistry, 2017, 72, 64-73.

2. Ya-Nan An1Xue Zhang1, Tian-Yuan Zhang, Meng-Yue Zhang, Qian-Zhang, Xiao-Yu Deng, Feng Zhao, Ling-Juan Zhu, Guan Wang, Jie Zhang, Yi-Xuan Zhang*, Bo Liu*, Xin-Sheng Yao*. Penicimenolides A-F, resorcylic acid lactones from Penicillium sp., isolated from the rhizosphere soil of Panax notoginsengScientific reports, 2016, 6, 27396.

3. Meng Ming, Xue Zhang*, Hai-Feng Chen, Ling-Juan Zhu, De-Quan Zeng, Jian Yang, Guang-Xun Wu, Yu-Zhuo Wu, Xin-Sheng Yao*. RXRα transcriptional inhibitors from the stems of Calophyllum membranaceumFitoterapia, 2016, 108, 66-72.

4. Ling-Juan Zhu1, Fei Yan1, Jin-Peng Chen, Nan Zhang, Xue Zhang*, Xin-Sheng Yao. 8-O-4' Neolignan glycosides from the aerial parts of Matteuccia struthiopterisChinese Chemical Letters, 2016, 27 (1), 63-65.

5. Jin Tian1, Jun-Jie Han1Xue Zhang*, Lu-Wei He, Yong-Jie Zhang, Li Bao, Hong-Wei Liu*. New cyclohexadepsipeptides from an entomogenous fungus Fusarium proliferatumand their cytotoxicity and autophagy-inducing activity. Chemistry & Biodiversity, 2016, 13 (7), 852-860.

6. Bo Li, Yang Ni, Ling-Juan Zhu, Feng-Bo Wu, Fei Yan, Xue Zhang*, Xin-Sheng Yao*. Flavonoids from Matteuccia struthiopteris and their anti-influenza virus (H1N1) activity. Journal of Natural Products, 2015, 78 (5), 987-995.

7. Ling-Juan Zhu1, Ming Ren1, Tie-Chui Yang, Cheng Qiao, Bei-Bei Chen, Zheng-Zhou Han, Shu-Hong Wang, Ping Wen, Xue Zhang*. Four new alkylamides from the roots of Zanthoxylum nitidumJournal of Asian Natural Products Research, 2015, 17 (7), 711-716.

8. Tao Xie1, Si-Jia Li1, Ming-Rui Guo1, Yue Wu, Hang-Yu Wang, Ke Zhang, Xue Zhang*, Liang Ouyang, Jie Liu*. Untangling knots between autophagic targets and candidate drugs, in cancer therapy. Cell Proliferation, 2015, 48 (2), 119-139.

9. Ling-Juan Zhu, Cheng Qiao, Xiu-Yu Shen, Xue Zhang*, Xin-Sheng Yao*. Iridoid glycosides from the roots of Scrophularia ningpoensis Hemsl. Chinese Chemical Letters, 2014, 25 (10), 1354-1356.

10. Ling-Juan Zhu, Yun-Long Hou, Xiu-Yu Shen, Xiao-Dong Pan, Xue Zhang*, Xin-Sheng Yao*. Monoterpene pyridine alkaloids and phenolics from Scrophularia ningpoensis and their cardioprotective effect. Fitoterapia, 2013, 88 (7), 44-49.

11. X. Zhang1, L.-X. Chen1, L. Ouyang1, Y. Cheng, B. Liu. Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Proliferation, 2012, 45 (5), 466-476.

12. Peng Shao1Xue Zhang1, Bo Li, Wei-Hua Jiao, Li-Jun Wu, Xin-Sheng Yao. New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalisChemical & Pharmaceutical Bulletin, 2010, 58 (12), 1650-1654.

13. Miao-Miao Jiang, Hao Gao, Yi Dai, Xue Zhang*, Nai-Li Wang, Xin-Sheng Yao*. Phenylpropanoid and lignan derivatives from Antiaris toxicaria and their effects on proliferation and differentiation of an osteoblast-like cell line. Planta Medica, 2009, 75 (4), 340-345.

14. Mo-Lian Ren, Xue Zhang*, Rong Ding, Yi Dai, Feng-Juan Tu, Yi-Yu Cheng, Xin-Sheng Yao*. Two new monoterpene glucosides from Paeonia lactiflora Pall.. Journal of Asian Natural Products Research, 2009, 11 (7), 670-674.

15. San-Lin Jin, Nai-Li Wang, Xue Zhang*, Yi Dai, Xin-Sheng Yao*. Two new xanthones from the stems of Cratoxylum cochinchinenseJournal of Asian Natural Products Research, 2009, 11 (4), 322-325.

16. Xue Zhang, Feng-Juan Tu, Hai-Yang Yu, Nai-Li Wang, Zhao Wang, Xin-Sheng Yao. Copacamphane, picrotoxane and cyclocopacamphane sesquiterpenes from Dendrobium nobileChemical & Pharmaceutical Bulletin, 2008, 56 (6), 854-857.

17. Xue Zhang, Jie-Kun Xu, Jue Wang, Nai-Li Wang, Hiroshi Kurihara, Sumumu Kitanaka, Xin-Sheng Yao. Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobileJournal of Natural Products, 2007, 70 (1), 24-28.

18. Xue Zhang, Hong-Wei Liu, Hao Gao, Hui-Ying Han, Nai-Li Wang, Hou-Ming Wu, Xin-Sheng Yao, Zhao Wang. Nine new sesquiterpenes from Dendrobium nobileHelvetica Chimica Acta, 2007, 90 (12), 2386-2394.

19. Xue Zhang, Hao Gao, Nai-Li Wang, Xin-Sheng Yao. Three new bibenzyl derivatives from Dendrobium nobileJournal of Asian Natural Products Research, 2006, 8 (1-2), 113-118.

20. 《有机化合物波谱解析》,中国医药科技出版社,20159月,参编。

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