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天然药物化学教研室

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李达翃 教师的资料

  李达翃

姓名: 李达翃             性别:             电话: 13840351554

联系电话: 024-23986465          E-Mail lidahong0203@163.com

职称/职务: 副教授          通讯地址: 沈阳市沈河区文化路103

学习/工作经历:

2003——2007年沈阳药科大学基础药学基地班本科阶段学习

2007——2010年沈阳药科大学药物化学专业硕士阶段学习

2010——2013年中国药科大学药物化学专业博士阶段学习

20138月至今沈阳药科大学中药学院教师

201411月至今沈阳药科大学/江苏康缘药业博士后

201510——20163月日本武库川女子大学访问学者

科研/获奖情况:

作为课题负责人主持国家自然科学基金面上项目1项(2018‒2021年,76.8万),国家自然科学基金青年基金项目1项(2016‒2018年,25.2万),国家博士后科学基金特别资助1项(2017年,15万),国家博士后科学基金面上资助(一等)1项(2015年,8万),辽宁省自然科学基金面上项目1项(2017年,5万),辽宁省教育厅科学研究项目2项,中央高校基本科研业务费专项基金1项,沈阳药科大学科研专项基金1项,沈阳药科大学中青年教师事业发展支持计划项目1项,省部级重点实验室开放课题2项,江苏省普通高校研究生科研创新计划项目1项;作为指导教师指导省级大学生创新创业项目2项,校级大学生创新创业项目1项;作为项目骨干成员参与十三五科技部重大专项课题1项,参与国家自然科学基金面上项目3项,辽宁省自然科学基金面上项目1项。

获得辽宁省百千万人才工程“万层次”人选,2015年辽宁省自然科学学术成果奖二等奖,2015年沈阳市自然科学学术成果奖二等奖,2016年沈阳市自然科学学术成果奖一等奖1项、二等奖2项,2015年、2016年中药学院教学工作先进个人、科研工作先进个人;2015-2016年校优秀班导师。作为唯一指导教师获得第一届全国医药院校药学/中药学大学生创新创业暨实验教学改革大赛特等奖,第二届辽宁省互联网+”大学生创新创业大赛铜奖。带领研究生参加各类学术活动,获得2016年世界华人药物化学研讨会最佳海报奖;2014年世界中联中药化学专业委员会第三届学术年会大会论文三等奖等奖项。

 教学/指导研究生情况:

讲授本科《天然药物化学》、《有机化合物波谱解析》和《国外植物药的研究与开发》等理论课程,及《天然药物化学实验》课程;研究生《植化方法学实验》课程。于天然药物化学专业已招收硕士研究生4人,并协助华会明教授指导博士研究生4人、硕士研究生7人。

发表论文/出版著作:

发表SCI论文50篇,其中第一作者24篇,通讯作者3篇。研究成果多次受邀在国际、国内学术会议上作报告。

通讯作者SCI论文3篇:

    (1) Tong Han, Jia Li, Jingjing Xue, He Li, Fanxing Xu*, Keguang Cheng, Dahong Li*, Zhanlin Li, Ming Gao, Huiming Hua*, Scutellarin derivatives as apoptosis inducers: design, synthesis and biological evaluation, Eur. J. Med. Chem. 2017, 135: 270-281

    (2) Kangtao Tian#, Fanxing Xu#, Xiang Gao, Tong Han, Jia Li, Huaqi Pan*, Linghe Zang, Dahong Li*, Zhanlin Li, Takahiro Uchita, Ming Gao, Huiming Hua*, Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents, Eur. J. Med. Chem. 2017, 136: 131-143

    (3) Nan Zhao#, Kangtao Tian#, Keguang Cheng, Tong Han, Xu Hu, Dahong Li*, Zhanlin Li, Huiming Hua*, Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine, Bioorg. Med. Chem. 2016, 24(13): 2971-2978

第一作者SCI论文24篇:

(1) Kaibo Wang#Dahong Li#, Yu Bao, Fei Cao, Wenjing Wang, Clement Lin, Wen Bin, Jiao Bai, Yuehu Pei, Yongkui Jing, Danzhou Yang*, Zhanlin Li*, Huiming Hua*, Structurally diverse alkaloids from the seeds of Peganum harmalaJ. Nat. Prod. 2017, 80(2): 551-559

(2) Ping Hu#Dahong Li#, Cuicui Jia, Quan Liu, Xiaofei Wang, Zhanlin Li*, Huiming Hua*, Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities, J. Funct. Foods 2017, 35: 236-244

(3) Dahong Li#, Ping Hu#, Shengtao Xu, Chunyan Fang, Shuang Tang, Xinyu Wang, Xingyan Sun, He Li, Ying Xu, Xiaoke Gu*, Jinyi Xu*, Lasiokaurin derivatives: Synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects, Arch. Pharm. Res. 2017, 40: 796-806

(4) Shengli Niu#Dahong Li#, Yuetong Wang, Kaibo Wang, Bin Lin, Yongkui Jing, Huiming Hua, Jiao Bai*, Zhanlin Li*, Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteataOrg. Biomol. Chem. 2017, 15: 4901-4906

    (5) Dahong Li, Tong Han, Xu Hu, Kangtao Tian, Shengtao Xu, Tingting Zhou, Keguang Cheng, Zhanlin Li*, Huiming Hua*, Jinyi Xu*, Synthesis, cytotoxicity and antimicrobial activity of new enmein-type kauranoid diterpenoid derivatives, Anticancer Agents Med. Chem.2017, doi: 10.2174/1871521409666170412114648

    (6) Yan Bai#Dahong Li#, Tingting Zhou, Ningbo Qin, Zhanlin Li, Zhiguo Yu*, Huiming Hua*, Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities, J. Funct. Foods 2016, 20: 453-462

    (7) Dahong Li, Xu Hu, Tong Han, Shengtao Xu, Tingting Zhou, Zhenzhong Wang*, Keguang Cheng, Zhanlin Li, Huiming Hua*, Wei Xiao, Jinyi Xu*, Synthesis, biological activity, and apoptotic properties of NO-donor/enmein-type ent-kauranoid hybrids, Int. J. Mol. Sci.2016, 17(6): e747

    (8) Chunmei Sai#Dahong Li#, Shengge Li, Tong Han, Yongzhi Guo, Yuehu Pei, Jiao Bai, Yongkui Jing, Zhanlin Li*, Huiming Hua*, Racemic alkaloids from Macleaya cordata: Structural elucidation, chiral resolution, and cytotoxic, antibacterial activities, RSC Adv. 2016, 6(47): 41173-41180

    (9) Dahong Li, Tong Han, Jie Liao, Xu Hu, Shengtao Xu, Kangtao Tian, Xiaoke Gu, Keguang Cheng*, Zhanlin Li, Huiming Hua*, Jinyi Xu*, Oridonin, a promising ent-kaurane diterpenoid lead compound, Int. J. Mol. Sci. 2016, 17(9): e1395

    (10) Dahong Li#, Chenxi Li#, Cuicui Jia, Yating Sun, Chunmei Xue, Jiao Bai, Huiming Hua, Xiaoqiu Liu*, Zhanlin Li*, Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells, Arch. Pharm. Res. 2016, 39(2): 172-177

    (11) Dahong Li#, Jia Guo#, Wen Bin, Nan Zhao, Kaibo Wang, Jianyong Li, Zhanlin Li*, Huiming Hua*, Two new benzylisoquinoline alkaloids from Thalictrum foliolosum and their antioxidant and in vitro antiproliferative properties, Arch. Pharm. Res. 2016, 39(7): 871-877

    (12) Dahong Li, Tong Han, Kangtao Tian, Shuang Tang, Shengtao Xu, Xu Hu, Lei Wang, Zhanlin Li, Huiming Hua*, Jinyi Xu*, Novel nitric oxide-releasing spirolactone-type diterpenoid derivatives with in vitro synergistic anticancer activity as apoptosis inducer, Bioorg. Med. Chem. Lett. 2016, 26(17): 4191-4196

    (13) Dahong Li, Tong Han, Shengtao Xu, Tingting Zhou, Kangtao Tian, Xu Hu, Keguang Cheng*, Zhanlin Li, Huiming Hua*, Jinyi Xu*, Antitumor and antibacterial derivatives of oridonin: A main composition of dong-ling-cao, Molecules 2016, 21(5): e575

    (14) Wenjia Kang#Dahong Li#, Tong Han, Lin Sun, Yanbin Fu, Chunmei Sai, Zhanlin Li*, Huiming Hua*, New chalcone and pterocarpoid derivatives from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property, Fitoterapia2016, 112: 222-228 

    (15) Ping Hu#Dahong Li#, Xu Hu, Shengge Li, Chunmei Sai, Xiaocong Sun, Tong Su, Jiao Bai, Zihou Wang, Zhanlin Li*, Huiming Hua*, Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation, Fitoterapia 2016, 111: 147-153

    (16) Dahong Li, Xu Hu, Tong Han, Jie Liao, Wei Xiao*, Shengtao Xu, Zhanlin Li, Zhenzhong Wang, Huiming Hua*, Jinyi Xu*, NO-releasing enmein-type diterpenoid derivatives with selective antiproliferative activity and effects on apoptosis-related proteins, Molecules 2016, 21(9): e1193

    (17) Dahong Li#, Tong Han#, Liping Guan, Jiao Bai, Nan Zhao, Zhanlin Li, Xin Wu*, Huiming Hua*, New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity, Nat. Prod. Res. 2016, 30(10): 1116-1122

    (18) Shengtao Xu#Dahong Li#, Lingling Pei, Hong Yao, Chengqian Wang, Hao Cai, Hequan Yao, Xiaoming Wu, Jinyi Xu*, Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives, Bioorg. Med. Chem. Lett. 2014, 24(13): 2811-2814

    (19) Dahong Li, Hao Cai, Bowen Jiang, Guyue Liu, Yuetong Wang, Lei Wang, Hequan Yao, Xiaoming Wu*, Yijun Sun, Jinyi Xu*, Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells, Eur. J. Med. Chem. 2013, 59: 322-328

    (20) Dahong Li#, Shengtao Xu#, Hao Cai, Lingling Pei, Hengyuan Zhang, Lei Wang, Hequan Yao, Xiaoming Wu, Jieyun Jiang, Yijun Sun, Jinyi Xu*, Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation, Eur. J. Med. Chem. 2013, 64: 215-221

    (21) Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Lei Wang, Xiaoming Wu, Hequan Yao, Jieyun Jiang, Yijun Sun, Jinyi Xu*, Library construction and biological evaluation of enmein-type diterpenoid analogs as potential anticancer agents, ChemMedChem 2013, 8(5): 812-818

    (22) Lei Wang#Dahong Li#, Shengtao Xu, Hequan Yao, Yihua Zhang*, Jieyun Jiang, Jinyi Xu*, The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents, Eur. J. Med. Chem. 2012, 52: 242-250

    (23) Dahong Li#, Lei Wang#, Hao Cai, Yihua Zhang*, Jinyi Xu*, Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents, Molecules 2012, 17(6): 7556-7568

    (24) Dahong Li#, Lei Wang#, Bowen Jiang, Yihua Zhang*, Yijun Sun, Jinyi Xu*, Synthesis of novel furozan-based nitric oxide-releasing derivatives of 1-oxo-oridonin with anti-proliferative activity, Chin. J. Nat. Med. 2012, 10(6): 471-476

    参与发表SCI论文23篇:

    (1) Shengtao Xu, Hong Yao, Shanshan Luo, Yunkai Zhang, Donghua Yang, Dahong Li, Guangyu Wang, Mei Hu, Yangyi Qiu, Xiaoming Wu, Hequan Yao*, Weijia Xie, Zhesheng Chen*, Jinyi Xu*, A novel potent anticancer compound optimized from a natural oridonin scaffold induces apoptosis and cell cycle arrest through the mitochondrial pathway, J. Med. Chem. 2017, 60(4): 1449-1468

    (2) Ningbo Qin, Cuicui Jia, Jun Xu, Dahong Li, Fanxing Xu, Jiao Bai, Zhanlin Li*, Huiming Hua*, New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities, Fitoterapia 2017, 119: 83-89

    (3) Shengtao Xu, Hong Yao, Lingling Pei, Mei Hu, Dahong Li, Yangyi Qiu, Guangyu Wang, Liang Wu*, Hequan Yao, Zheying Zhu*, Jinyi Xu*, Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation, Eur. J. Med. Chem. 2017, 132: 310-321

    (4) Ningbo Qin, Shengge Li, Xueyuan Yang, Chi Gong, Xiangyu Zhang, Jian Wang*Dahong Li, Yuanqiang Guo, Zhanlin Li, Huiming Hua*, Bioactive terpenoids from Silybum marianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS, Bioorg. Med. Chem. Lett. 2017, 27: 2161-2165

    (5) Cuicui Jia, Tong Han, Jun Xu, Shengge Li, Yating Sun, Dahong Li, Zhanlin Li*, Huiming Hua*, New biflavonoid and triterpene from the leaves of Garcinia paucinervis and their biological activities, J. Nat. Med. 2017, accepted.

    (6) Sayuko Shiraishi, Tamami Haraguchi, Saki Nakamura, Dahong Li, Honami Kojima, Miyako Yoshida, Takahiro Uchida*, Taste-masking effect of chlorogenic acid (CGA) on bitter drugs evaluated by taste sensor and surface plasmon resonance on the basis of CGA-drug interactions, Chem. Pharm. Bull. 2017, 65(2): 127-133

    (7) Kaibo Wang, Dahong Li, Ping Hu, Wenjing Wang, Clement Lin, Jian Wang, Bin Lin, Jiao Bai, Yuehu Pei, Yongkui Jing, Zhanlin Li*, Danzhou Yang*, Huiming Hua*, A series of β-carboline alkaloids from the seeds of Peganum harmala show G-quadruplex interactions, Org. Lett. 2016,18(14): 3398-3401

    (8) Chunmei Sai, Ningbo Qin, Cuicui Jia, Dahong Li, Kaibo Wang, Yuehu Pei, Jiao Bai, Zhanlin Li*, Huiming Hua*, Macleayine, a new alkaloid from Macleaya cordataChin. Chem. Lett. 2016, 27(11): 1717-1720

    (9) Zhiguo Liu, Zhanlin Li, Dahong Li, Ning Li, Jiao Bai, Feng Zhao*, Dali Meng*, Huiming Hua*ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolatawith their inhibitory activities on LPS-induced NO production in RAW 264.7 macrophages, Bioorg. Med. Chem. Lett. 2016, 26(1): 1-5

    (10) Yating Sun, Dahong Li, Cuicui Jia, Chunmei Xue, Jiao Bai, Zhanlin Li*, Huiming Hua*, Three new xanthones from the leaves of Garcinia lancilimbaJ. Nat. Med. 2016, 70(2): 173-178

    (11) Yu Wang, Dahong Li, Zhanlin Li, Yanjun Sun, Huiming Hua , Tao Liu*, Jiao Bai*, Terpenoids from the marine-derived fungus Aspergillus fumigatus YK-7, Molecules 2016, 21(1): e31

    (12) Zhanlin Li*, Yuan Li, Ningbo Qin, Dahong Li, Zhiguo Liu, Qian Liu*, Huiming Hua, Four new coumarins from the leaves of Calophyllum inophyllumPhytochem. Lett. 2016, 16: 203-206

    (13) Chunmei Sai, Dahong Li, Chunmei Xue, Kaibo Wang, Ping Hu, Yuehu Pei, Jiao Bai, Yongkui Jing, Zhanlin Li*, Huiming Hua*, Two pairs of enantiomeric alkaloid dimers from Macleaya cordataOrg. Lett. 2015,17(16): 4102-4105

    (14) Nan Zhao, Zhanlin Li*Dahong Li, Yating Sun, Dongting Shan, Jiao Bai, Yuehu Pei, Yongkui Jing, Huiming Hua*, Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines, Phytochemistry 2015, 109: 133-139

    (15) Ping Hu, Dahong Li, Kaibo Wang, Hao Wang, Zihou Wang, Zhanlin Li*, Huiming Hua*, New phenolic compounds from Vitex negundo var. heterophylla and their antioxidant and NO inhibitory activities, J. Funct. Foods 2015, 19: 174-181

    (16) Ningbo Qin, Aoli Wang, Dahong Li, Kaibo Wang, Bin Lin, Zhanlin Li*, Huiming Hua*, Cytotoxic clerodane furanoditerpenoids from the root of Tinospora sagittataPhytochem. Lett. 2015, 12: 173-176

    (17) Nan Zhao, Guochun Yang, Dahong Li, Xinyu Li, Zhanlin Li, Jiao Bai, Xiaoqiu Liu*, Huiming Hua*, Two new sesquiterpenes from Myrrh, Helv. Chim. Acta. 2015, 98(9): 1332-1336

    (18) Kaibo Wang, Yingtong Di, Yu Bao, Chunmao Yuan, Gang Chen, Dahong Li, Jiao Bai, Hongping He, Xiaojiang Hao, Yuehu Pei, Yongkui Jing, Zhanlin Li*, Huiming Hua*, Peganumine A, a β-Carboline dimer with a new octacyclic scaffold from Peganum harmalaOrg. Lett. 2014, 16(15): 4028-4031

    (19) Kaibo Wang, Chunmao Yuan, Chunmei Xue, Dahong Li, Yongkui Jing, Hongping He, Xiaojiang Hao, Yingtong Di, Zhanlin Li*, Huiming Hua*, Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmalaRSC Adv. 2014, 4(96): 53725-53729

    (20) Shengtao Xu, Lingling Pei, Chengqian Wang, Yunkai Zhang, Dahong Li, Hequan Yao, Xiaoming Wu, Zhesheng Chen*, Yijun Sun, Jinyi Xu*, Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates, ACS Med. Chem. Lett.2014, 5(7): 797~802

    (21) Shengtao Xu, Lingling Pei, Dahong Li, Hong Yao, Hao Cai, Hequan Yao, Xiaoming Wu, Jinyi Xu*, Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives, Fitoterapia 2014, 99: 300-306

    (22) Lei Wang, Dahong Li, Chaolei Wang, Yihua Zhang*, Jinyi Xu*, Recent progress in the development of natural ent-kaurane diterpenoids with anti-tumor activity, Mini Rev. Med. Chem. 2011, 11(10): 910-919

(23) Lei Wang, Qian Ran, Dahong Li, Hequan Yao, Yihua Zhang*, Shengtao Yuan, Luyong Zhang, Mingqin Shen, Jinyi Xu*, Synthesis and anti-tumor activity of 14-O-derivatives of natural oridonin, Chin. J. Nat. Med. 2011, 9(3): 194-198

发明专利:

    申请发明专利20项(第一发明人8项),授权9项(第一发明人2项)。

获得9项授权发明专利如下:

    (1)李达翃,华会明,李占林,赵楠,田康涛,韩通,胡旭,方春艳,一类具有抗肿瘤活性的硝酸酯类NO供体型吴茱萸碱衍生物,CN201610020347.1

    (2)李达翃,华会明,李占林,赵楠,田康涛,韩通,胡旭,方春艳,一类具有抗肿瘤活性的呋咱类NO供体型吴茱萸碱衍生物,2017.03.03,中国,CN201610016630.7

    (3)徐进宜,李达翃,蔡浩,王磊,徐盛涛,孙飞,姚和权,蒋洁云,孙益军,具有抗肿瘤活性的冬凌草甲素及6,7-开环冬凌草甲素含氟衍生物、制备方法及用途,CN201110254258.0

    (4)华会明,苏钰清,马冬珂,李圣各,李达翃,李建勇,郭佳,马尾连中两个含氯取代的抗肿瘤苄基异喹啉生物碱,CN201410033024.7

    (5)徐进宜,徐盛涛,李达翃,王诚倩,姚鸿,裴玲玲,陈哲生,张运闿,张恒源,张晨曦,冬凌草甲素14-O-取代氮芥衍生物、制备方法及用途,CN201410196592.9

    (6)徐进宜,李达翃,徐盛涛,周志文,张恒源,蔡浩,杨雪,裴玲玲,姚和权,吴晓明,谢唯佳,1,6,7,14-位取代的冬凌草甲素衍生物、制备方法及用途,CN201310423035.1

    (7)徐进宜,徐盛涛,裴玲玲,李达翃,姚鸿,蔡浩,周志文,张恒源,杨雪,姚和权,吴晓明,谢唯佳,冬凌草甲素及其ent-6,7-开环贝壳杉烯型衍生物在制备抗结核药物方面的用途,CN201410161219.X

    (8)徐进宜,王磊,张奕华,姚和权,李达翃,徐盛涛,黄晓静,张恒源,李德尧,郭建曼,王国财,一氧化氮供体型冬凌草甲素14位羟基修饰衍生物、其制备方法及用途,CN201110178862.X

    (9)徐进宜,萧伟,李赞,丁岗,李达翃,孟兆青,王振中,曹亮,李娜,刘文君,一种抗肿瘤、抗病毒的化合物、其制备方法及用途,CN201210083954.4